This blog is #20 in a series of blogs in the form of questions or statements about a health issue and answers. These are in the typical format used when doctors take tests.
Which of the following classes of drugs inhibits enzymes (DDAH, ADMA) needed to convert nitrites to nitric oxide, which may inhibit their vasodilating effects?
A. H2 blockers
B. Proton pump inhibitors
C. Tricyclic antidepressants
D. H1 blockers
E. Serotonin reuptake inhibitors
That’s correct. B. Proton pump inhibitors.
Proton pump inhibitors (but not H2 blockers) inhibit enzymes needed for the body to convert nitrites to nitric oxide, which may interfere with the health benefits of a plant-based diet and possibly explain the high risk for myocardial infarction (heart attacks) seen with long-tern use of these drugs.
Shah NH, LePendu P, Bauer-Mehren A, et al. Proton pump inhibitor usage and the risk of myocardial infarction in the general population. PLoS One 10:e0124653, 2015.
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